Statin and clarithromycin interaction
WebUse WebMD’s Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. WebJun 6, 2024 · Although rare, a serious complication of statin therapy is liver toxicity with elevated levels of transaminases. Due to a potential increase in liver enzymes, patients with active liver disease and pre-existing elevated …
Statin and clarithromycin interaction
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WebBoth Simvastatin and Clavulanate can increase the risk of hepatotoxicity. Cobicistat Cobicistat is predicted to increase the exposure to Simvastatin. Manufacturer advises … WebFeb 5, 2024 · Some medications may interact with statins by decreasing the effectiveness of the statin. Others may increase the statin level in the blood to the point where it may …
WebAbstract. Statins are commonly used in the treatment of hyperlipidaemia. Although the benefits of statins are well-documented, they have the potential to cause myopathy and rhabdomyolysis due to the complex interactions of drugs, comorbidities and genetics. The cytochrome P450 family consists of major enzymes involved in drug metabolism and ... WebDec 11, 2014 · A full updated listing of all the interactions is provided in the table below. Drug interactions associated with increased risk of myopathy/rhabdomyolysis Interacting …
WebFifty-two patients (0.9%) in the 80-mg group versus one patient (0.02%) in the 20-mg group developed myopathy (defined as unexplained muscle weakness or pain with a serum CK >10 times the upper... Webclarithromycin oral and simvastatin oral clarithromycin oral will increase the level or effect of simvastatin oral by altering drug metabolism. May cause muscle ache, muscle pain, weakness, and dehydration. Patient Drug Interactions Source: RxList © 2024 RxList, Inc. Check for more interactions with the Drug Interaction Checker Check Now »
WebClarithromycin, like other macrolides, is an inhibitor of CYP450 3A4, the major enzyme responsible for the metabolism of several drugs, in particular some statins. Rhabdomyolysis related to macrolide–statin interaction has previously been described. To date, rhabdomyolysis induced by clarithromycin has been described in only one previous report.
WebJan 9, 2024 · The more common side effects of clarithromycin oral tablet can include: stomach pain diarrhea nausea vomiting abnormal taste in your mouth If these effects are mild, they may go away within a... cheer pheasant in hindiWebBackground: Simvastatin is a HMG-CoA reductase Inhibitor and a substrate of CYP3A4. Clarithromycin is a commonly used macrolide antibiotics and a potent inhibitor of CYP3A4. When co-administered with simvastatin, clarithromycin can significantly increase simvastatin plasma concentration levels, thereby, increase the risk of rhabdomyolysis. cheer performanceWebApr 1, 2024 · Other Interactions Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. cheer phi leaderWebQuetiapine — concurrent use is contraindicated. If necessary, monitor for adverse effects. Sildenafil, tadalafil — dose reductions may be necessary. Statins — concurrent administration with clarithromycin increases their plasma levels and the risk of myopathy. Lovastatin, simvastatin — concurrent use is contraindicated. flawg20s2 neffWebMay 1, 2024 · These interactions can lead to an increase in statin concentration, thus increasing the risk of muscle toxicity. 32, 33 Atorvastatin undergoes less metabolism by CYP3A4, but some cases of myopathy ... cheer pheasants for saleWebAug 7, 2024 · Answer There is a potentially significant interaction between azithromycin, the antibiotic in the Z-Pak, and Lipitor (atorvastatin), a ' statin ' cholesterol drug. However, data is conflicting in regard to just how risky the combination is. cheer phone svgWebKnowing potential drug-drug interactions as well as how the patient and physician interact interpersonally is necessary for optimal medication use. Elderly… flawg20s2