Stat1 mouse
WebLoss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden Type I and type II classes of interferons (IFNs) signal through the JAK/STAT1 pathway and are known to be important in adaptive and innate immune responses and in protection against tumors. WebPrimePCR™ SYBR® Green Assay: Stat1, Mouse Signal transducer and activator of transcription 1 Assay Type: SYBR® Green Assay Design: exonic Application: Gene …
Stat1 mouse
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Web012901 B6;129S- Stat1 tm1Mam /Mmjax These Stat1 fl (signal transducer and activator of transcription 1) mutant mice may be useful in generating conditional mutations to study … WebMay 25, 2000 · Stat1 is a fascinating and complex protein with multiple, yet contrasting transcriptional functions. ... IFNγ suppresses c-myc expression in wild-type but not in …
WebThe Stat1 mouse was developed in the laboratory of Robert Schreiber at the Washington University School of Medicine. The model was created by targeting the Stat1 gene in GS-1 … WebSep 29, 2024 · We found that disruption of IFN-γ–STAT1 signaling in mouse and human adipocytes relieves WAT inflammation and replenishes tricarboxylic acid (TCA) metabolites. Mechanistically, STAT1 broadly represses gene programs involved in fatty acid metabolism and oxidative phosphorylation.
WebStat1 was detected using Stat1 Antibody #9172, and p42 was detected using p42 MAPK Antibody #9108. The Stat1 Antibody confirms silencing of Stat1 expression, and the p42 MAPK Antibody is used to control for protein loading and siRNA specificity. Western blot analysis of extracts from SK-MEL-28 cells, untreated or IFN-alpha-treated (100 ng/ml ... WebFeb 9, 1996 · To study the requirement for STAT1 in vivo, we disrupted the Stat1 gene in embryonic stem (ES) cells and in mice. Stat1 (-1-)ES cells were unresponsive to interferon (IFN), but retained responsiveness to leukemia inhibitory factor (LIF) and remained LIF dependent for undifferentiated growth.
WebSTAT1 (pY701) ELISA Kit is a very rapid, convenient and sensitive assay kit that can monitor the activation or function of important biological pathways in human and mouse cell lysates. By determining phosphorylated STAT1 protein in your experimental model system, you can verify pathway activation in your cell lysates.
WebThe STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. telesat canada ltdhttp://sigma-aldrich.cnreagent.com/pdetail407557.html telesat market capWeb012901 B6;129S- Stat1 tm1Mam /Mmjax These Stat1 fl (signal transducer and activator of transcription 1) mutant mice may be useful in generating conditional mutations to study autonomous roles of STAT1 in ERBB2/neu induced mammary tumorigenesis. If you need help with your order ... MOUSE GENOME INFORMATICS. telesat newsWebStat1 (9H2) Mouse mAb detects endogenous levels of total Stat1 protein independent of phosphorylation, however, it prefers the non-phosphorylated form of Stat1. The antibody … telesat leo delayWebStat1 Organism names Organism Mus musculus (Mouse) Taxonomic identifier 10090 NCBI Taxonomic lineage Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > … telesat tv user manualWebSep 9, 2024 · We first examined the expression profiles of STAT1 in mouse brains after unilateral CCI, a model of moderate to severe TBI. Flow cytometry was used to identify major cell types in the brain, such as Mi/MΦ, astrocytes, oligodendrocytes, and other CNS cells, and to quantify STAT1-expressing cells at the acute (2 h) and subacute (24 and 72 h ... telesat canada thalesWebIt can be used for measuring the relative amount of Stat1 (pTyr 701), Stat3 (pTyr 705) and Stat5 (pTyr 694) phosphorylation and screening the effect of various treatment, inhibitors (such as siRNA or chemicals), or activators in cultured human, mouse and rat cell lines (Stat5 only can be used for detecting human cell lines). 免疫原 telesat ottawa