Low theophylline level
Web3 nov. 2024 · He was taken to hospital by ambulance after admitting that he had ingested an overdose of his theophylline tablets. He said that he ingested 25 x 300mg theophylline SR tablets 1.5 hours previously and … Web22 apr. 2024 · After 3 more days, your dose may be adjusted as needed based on the level of theophylline in your blood. Child dosage (ages 1–15 years who weigh less than 45 kg) The starting dose is 12–14 mg ...
Low theophylline level
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WebIf concomitant use cannot be avoided, monitor theophylline levels and adjust dosage as needed. ciprofloxacin will increase the level or effect of theophylline by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Concomitant use of theophylline and ciprofloxacin has decreased theophylline clearance and ... Web1 jan. 2003 · Patients with pulmonary hypertension had earlier disease onset, lower forced expiratory flow of 25-75%, lower arterial oxygen tension and lower pre-6MWT SpO2 (p < 0.05), older age, and lower SpO2 ...
WebFor example; concomitant administration of CYP450 enzyme inducers phenytoin, or rifampicin, result in low theophylline plasma levels, thus higher doses may be required. Decreased clearance of theophylline may be seen with liver disease, and heart failure, and therefore appropriate dose reduction and monitoring of plasma levels is required . Web4 okt. 2024 · Discontinuation of a concomitant drug that inhibits theophylline clearance will result in decreased serum theophylline concentrations, unless the theophylline dose is appropriately increased. The drugs listed in Table III have either been documented not to interact with theophylline or do not produce a clinically significant interaction (i.e., < …
Web3 feb. 2024 · Theophylline distributes poorly into body fat, therefore mg/kg doses should be calculated on the basis of lean (ideal) bodyweight. Plasma theophylline concentrations should ideally be maintained between 5 and 12 micrograms/ml. A plasma level of 5 micrograms/ml probably represents the lower level of clinical effectiveness. WebPremature infants have very low rates of theophylline elimination. Conversely, theophylline elimination is more rapid among cigarette smokers. In combination with other clinical data, monitoring serum theophylline levels may provide the physician with useful information to aid in adjusting patient dosage to achieve optimal therapeutic effect while …
Web1 sep. 1976 · Although only modest doses of oral theophylline were being administered at the time of the convulsion the serum theophylline level was markedly raised and the theophylline clearance was very low.
Web21 mrt. 2024 · Theophylline has a low therapeutic index: the serum concentration required for therapeutic effect is close to that which results in toxic symptoms. Although the serum level for therapeutic effect has been established, the dose required to attain this therapeutic level varies, so that all patients should have their serum concentration checked during … edtbookshopWebMedications included lisinopril 10 mg/d, which had been started six weeks earlier, sustained-release theophylline 300 mg q12h, and an albuterol inhaler. The lisinopril was discontinued on admission. Serum sodium concentration was 109 mmol/L; the osmolality of the blood and of the urine were 253 mOsmol and 438 mOsmol, respectively, with a specific gravity of … ed taylor seattleWeb31 aug. 2024 · low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or … constructing a good thesis statementWeb21 sep. 2024 · National Center for Biotechnology Information edt bearing catalog pdfWebTherapeutic drug monitoring. In most individuals, a plasma-theophylline concentration of 10–20 mg/litre (55–110 micromol/litre) is required for satisfactory bronchodilation, … edt capital pty ltdWeb9 apr. 2024 · In spite of contradictory evidence, the use of low-dose theophylline (plasma concentration 1–5 mg/L) in COPD has received attention owing to its potential synergism with inhaled corticosteroids. In patients with COPD, even high doses of inhaled corticosteroids can fail to suppress airway inflammation. ed-tboxbWebDecreased effect/increased toxicity: Changes in diet may affect the elimination of theophylline; ... ncreased theophylline level: Allopurinol (>600 mg/day), beta-blockers, calcium channel blockers, carbamazepine, CHF, cimetidine, ciprofloxacin, cor pulmonale, corticosteroids, ... edtc company