Lamp2a knockout mouse
Webb兔多克隆抗体to LAMP2A - Lysosome Marker 宿主 Rabbit 经测试应用 适用于: WB, ICC/IF, IHC-P more details 种属反应性 与反应: Mouse, Human 预测可用于: Dog, Monkey, Chinese hamster 免疫原 Synthetic peptide corresponding to Human LAMP2A aa 350 to the C-terminus (C terminal) conjugated to keyhole limpet haemocyanin. LAMP2 has 3 … Webb13 nov. 2014 · Rett syndrome (RTT) is a genetic disorder characterized by a range of features including cognitive impairment, gait abnormalities and a reduction in purposeful hand skills. Mice harbouring knockout mutations in the Mecp2 gene display many RTT-like characteristics and are central to efforts to find novel therapies for the disorder. As …
Lamp2a knockout mouse
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Webb12 apr. 2024 · In cellular and mouse models of HD, LAMP2A, and Hsc70 were markedly increased (Koga et al., 2011). ... In this depression model, cells were engineered to knockout FKBP51 and Akt1/2 and treated with different antidepressants, including paroxetine, amitriptyline, ... WebbLAMP2A protein levels, as studied by immunohistochemistry, showed a decreased immunoreactivity in P2X7 receptor-deleted mice, having been exposed to toxin or MCD diet compared with the...
WebbLAMP2A localization in Ctns / cells but not Rab11 defects. Theup-regulationofRab11,Rab7,orRILP,butnotitstruncated form RILP-C33, rescued LAMP2A-defective trafficking in cys-tinosis, whereas dominant-negative Rab11 or Rab7 impaired LAMP2A trafficking. Treatment of cystinotic cells with a CMA activator increased … WebbLiver-specific LAMP2A-knockout mice and HepG2 cells lacking LAMP2A [L2A(-) cells] were used to investigate the influence of CMA on lipolysis in hepatocytes. The …
WebbLane 2 : LAMP2 knockout HEK-293 (Human epithelial cell line from embryonic kidney) whole cell lysate at 20 µg Lane 3 : Hep G2 (Human liver hepatocellular carcinoma cell … WebbThe NIH-3T3 mouse embryonic fibroblast cells (American Type Culture Collection, CRL-1658™) were cultured in a 37°C incubator with 5% CO 2 in DMEM medium supplemented with 10% newborn calf serum (NCS). Mouse embryonic fibroblasts (MEFs) were generated from lamp2a null mice and corresponding wild-type littermates as described previously.
WebbIn this work, we identified and validated 2 NFE2L2 binding sequences in the LAMP2 gene and demonstrated in several human and mouse cell types that NFE2L2 deficiency and …
WebbAutophagy in hepatocellular carcinomas: from pathophysiology to therapeutic response Srikanta Dash,1,2 Srinivas Chava,1 Partha K Chandra,1 Yucel Aydin,2 Luis A Balart,2 Tong Wu1 1Department of Pathology and Laboratory Medicine, 2Department of Gastroenterology and Hepatology, Tulane University School of Medicine, New Orleans, … 5福1安Webb8 mars 2024 · Furthermore, an increased number and size of LDs and an accumulation of CE and TAG occurs in the liver from Lamp2A-knockout mouse. In addition, accumulation of TAG precursors, such as FFAs and DAG, is detected after 24 h of starvation, demonstrating an inadequate adaptation of the peripheral adipose tissue to the lipid … 5神 模拟人生4Webb7 juli 2024 · The role of chaperone-mediated autophagy (CMA) in cancer initiation and progression is not well understood due to the lack of a loss-of-function cancer models of LAMP2A, the key regulator of this process. Here, by generating an isoform-specific knockout of LAMP2A, we show that CMA deficiency promotes proliferation and tumor … 5神龙烈焰WebbImmunohistochemical analysis of paraffin-embedded Mouse liver labeling LAMP2A with unpurified ab125068 at 1/500 dilution, followed by Goat Anti-Rabbit IgG H&L (HRP) at … 5神绅士包WebbLAMP2A knockout results in a decreased CMA activity, which leads to increased PLIN2 expression, decreased lipid oxidation and subsequent LD accumulation [ 4, 6 ]. LAMP2A being the rate-limiting factor of CMA, its expression and/or stabilization of the protein is crucial to that process. 5祝日5私人影院播放器WebbThe expression of LAMP2 isoform LAMP2A, not LAMP2B, was significantly downregulated in BTZ-resistant patients with MM compared the BTZ-sensitive patients with MM ... the downregulation of LAMP2 in the lung cancer cells increased their resistance to Temozolomide. 26 In LAMP1/LAMP2 double-knockout mice, ... 5神獣