WebHATRIC-LRC enabled, next to SCRB1, the identification of the receptor tyrosine-protein kinase Mer (MERTK). Through RNA interference, we revealed its contribution to endothelial HDL binding and uptake. Webhatric-lrc further enables the identification of complex extracellular interactomes, such as the host receptor panel for influenza A virus (IAV), the causative agent of the common flu.

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WebApr 17, 2024 · As HATRIC-LRC is based on protein-level purification, more than one peptide is commonly identified per protein, such as exemplified by EGFR (Supplementary Fig. 4). Therefore, we investigated the HATRIC-LRC detection limit with respect to the amount of starting material needed for successful receptor identification. WebApr 6, 2012 · We validated this ligand-based, receptor-capture (LRC) technology using insulin, transferrin, apelin, epidermal growth factor, the therapeutic antibody trastuzumab … masonite for floor protection

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WebThe data protection declaration of the Dualsystems Biotech AG is based on the terms used by the European legislator for the adoption of the General Data Protection Regulation (GDPR). Our data protection declaration should be legible and understandable for the general public, as well as our customers and business partners. WebJul 27, 2024 · Using LRC-TriCEPS it was shown that even low-expressed receptors of weak binding ligands can be identified. The TriCEPS and Hatric technologies are tools to perform mode of action studies for target identification on the living cells for drug candidates/ligands such as peptides, antibodies, ADC’s, proteins and small molecules. WebDownload scientific diagram HATRIC-LRC identifies target receptors for ligands ranging from small molecules to intact viruses. All results of HATRIC-LRC experiments are presented in volcano ... masonite for moving