Chlorthalidone versus hydrochlorthiazide nejm
WebFeb 27, 2016 · Hydrochlorothiazide is the more commonly prescribed thiazide diuretic, but chlorthalidone may have greater benefits. Studies have found that chlorthalidone provides greater blood pressure lowering effects over a 24-hour period than HCTZ. Prescribers need to be made aware of the potential for chlorthalidone for patients with … WebChlorthalidone reduces systolic blood pressure (SBP) by 10 mm Hg more than hydrochlorothiazide at equal dosages (12.5 to 25 mg daily) in patients using …
Chlorthalidone versus hydrochlorthiazide nejm
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WebFeb 25, 2024 · Chlorthalidone vs. Hydrochlorothiazide for Hypertension Thomas L. Schwenk, MD and Allan S. Brett, MD, reviewing Hripcsak G et al. JAMA Intern Med 2024 … WebJan 23, 2024 · This large VA clinical trial found that the blood pressure drug chlorthalidone (CTD) was not superior to hydrochlorothiazide (HCTZ) for the prevention of cardiovascular disease or non-cancer death. Both …
WebOct 4, 2024 · There are several added benefits to using chlorthalidone, as compared with other diuretics. A recent meta-analysis comparing hydrochlorothiazide, chlorthalidone, and bendroflumethiazide showed that chlorthalidone is almost three times more potent than hydrochlorothiazide, in addition to having a longer duration of action. [12] WebDec 14, 2024 · CONCLUSIONS: In this large pragmatic trial of thiazide diuretics at doses commonly used in clinical practice, patients who received chlorthalidone did not have a lower occurrence of major cardiovascular outcome events or non-cancer-related deaths than patients who received hydrochlorothiazide.
WebNov 5, 2024 · The Chlorthalidone in Chronic Kidney Disease (CLICK) Trial was a double-blind, randomized, placebo-controlled trial of … WebFeb 17, 2024 · Chlorthalidone, the guideline-recommended diuretic for lowering blood pressure, causes more serious side effects than hydrochlorothiazide, a similarly effective diuretic, according to a new...
WebEvidence-Based Answer Chlorthalidone reduces systolic blood pressure (SBP) by 10 mm Hg more than hydrochlorothiazide at equal dosages (12.5 to 25 mg daily) in patients using monotherapy....
WebJan 3, 2024 · Hydrochlorothiazide vs. Chlorthalidone for Hypertension Allan S. Brett, MD, reviewing Ishani A et al. N Engl J Med 2024 Dec 29 A randomized trial showed no difference in cardiovascular outcomes or … st john all inclusivesWebJun 1, 2024 · Chlorthalidone versus hydrochlorothiazide: major cardiovascular events, blood pressure, left ventricular mass, and adverse effects Over the short-term there were … st john ambulance accident bookWebMar 2, 2015 · Indapamide Versus Chlorthalidone. The first 2 authors of this article have been involved in studies documenting a longer and stronger antihypertensive effect of chlorthalidone over hydrochlorothiazide, studies that were published as far back as 2004 3 and reiterated in the current article with data from 3 head-to-head comparisons. 1. No … st john all inclusive resorts for familiesWebFeb 7, 2024 · On the other hand, chlorthalidone is considered a ‘thiazide-like’ diuretic, with peak levels reached 2-6 hours after oral administration. Its half-life is a lengthy 40 hours (single dose) or 45-60 hours (long-term), with a large degree of interindividual variability. Chlorthalidone is approximately 1.5 to 2 times more potent than HCTZ to dose. st john \u0026 paul catholic churchWebFeb 24, 2024 · Overall, 6756 patients were assigned to the chlorthalidone treatment group and 6767 were assigned to the hydrochlorothiazide treatment group. The mean participant age was 72 years. Overall, 97% of the patients were men, 15% were Black, 10.8% had a history of stroke or MI, and 45% resided in rural locations. st john allentownWebFeb 24, 2024 · Recognizing that whether chlorthalidone is superior to hydrochlorothiazide for the prevention of major CV events remains unclear, … st john ambulance accounts departmentWebDec 14, 2024 · At a median follow-up of 2.4 years, there was little difference in the occurrence of primary-outcome events between the chlorthalidone group (702 patients … st john all inclusive resorts